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Product Name
KISS1R-Specific antibody
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Description
KISS1R-Specific Rabbit Polyclonal antibody. Positive IF detected in MCF-7. Positive WB detected in SH-SY5Y cells, MCF7 cells. Observed molecular weight by Western-blot: 43-45kd,75kd
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Tested applications
ELISA, WB, IF
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Species reactivity
human; other species not tested.
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Alternative names
KISS1R antibody; KISS1 receptor antibody; HOT7T175 antibody; Hypogonadotropin 1 antibody; AXOR12 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_032551). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IF: 1:10-1:100
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Validations
SH-SY5Y cells were subjected to SDS PAGE followed by western blot with Catalog No:112072(KISS1R-Specific antibody) at dilution of 1:400
Immunofluorescent analysis of MCF-7 cells, using KISS1R antibody Catalog No:112072 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
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Background
receptor for metastin (kisspeptin-54, 13, 14, 10), C- terminally amidated peptides of KiSS-1. KiSS-1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some other carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.
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