KIR2DL3 antibody

Cat.#: 112060

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Product Information

  • Product Name
    KIR2DL3 antibody
  • Documents
  • Description
    KIR2DL3 Rabbit Polyclonal antibody. Positive WB detected in human liver tissue. Observed molecular weight by Western-blot: 58 kDa
  • Tested applications
    ELISA, WB
  • Species reactivity
    human; other species not tested.
  • Alternative names
    KIR2DL3 antibody; CD158B2 antibody; NKAT2 antibody; MHC class I NK cell receptor antibody; KIR K7c antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of KIR2DL3 recombinant protein (Accession Number: NM_015868). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

  • Validations

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:112060(KIR2DL3 antibody) at dilution of 1:500

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:112060(KIR2DL3 antibody) at dilution of 1:500

  • Background
    Killer cell immunoglobulin-like receptors (KIRs) are a diverse family of inhibitory and activating receptors expressed on NK cells and a subset of T cells (PMID: 11861603). These polymorphic receptors interact with specific motifs on HLA class I molecules, modulate NK cytolytic activity and are encoded by genes located on chromosome 19q13.4 (PMID: 17069649). KIR2DL3, also known as CD158B2 or NKAT2, is an inhibitory receptor that is specific for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7) (PMID: 10196125). It is a 341-amino acid transmembrane glycoprotein consisting of an extracellular region containing two C2-type Ig-like domains, a 19-amino acid hydrophobic transmembrane region, and a long cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory motifs (ITIMs). KIR2DL3 inhibits the cytolytic activity of NK cells thus preventing cell lysis (PMID: 7724594).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"