ITM2C antibody

Cat.#: 111954

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Product Information

  • Product Name
    ITM2C antibody
  • Documents
  • Description
    ITM2C Rabbit Polyclonal antibody. Positive IHC detected in human colon tissue. Positive WB detected in Transfected HEK-293 cells. Observed molecular weight by Western-blot: 30 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    BRI3 antibody; BRICD2C antibody; Cerebral protein 14 antibody; E25 antibody; E25C antibody; integral membrane protein 2C antibody; ITM2C antibody; ITM3 antibody; PSEC0047 antibody; Transmembrane protein BRI3 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of ITM2C recombinant protein (Accession Number: NM_001012516). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:111954(ITM2C Antibody) at dilution of 1:1000

    Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:111954(ITM2C Antibody) at dilution of 1:1000

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:111954(ITM2C Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:111954(ITM2C Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:111954(ITM2C Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:111954(ITM2C Antibody) at dilution of 1:50 (under 40x lens)

    Immunofluorescent analysis of HepG2 cells using Catalog No:111954(ITM2C Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of HepG2 cells using Catalog No:111954(ITM2C Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"