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Product Name
Mouse IL-17R/IL-17RA ?CD217? (His Tag) recombinant protein
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Description
Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling (By similarity).
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Protein name
Interleukin-17 receptor A
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Protein short names
IL17R; CDW217; HIL-17R; IL-17R; IL-17RA; AW538159; MGC10262; VDW217; IL17RA; CANDF5; CD217
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Uniprot ID
Q60943
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Gene Name
Il17ra; Il17r
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse IL17RA (NP_032385.1) extracellular domain (Met 1-Trp 322) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse IL17RA consists of 302 amino acids and has a predicted molecular mass of 34.8 kDa. As a result of glycosylation, the apparent molecular mass of rmIL17RA is approximately 55-60 kDa in SDS-PAGE under reducing conditions.
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Purity
> 98 % as determined by SDS-PAGE
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Activity
1. Measured by its binding ability in a functional ELISA.
2. Immobilized recombinant human IL17A at 2 μg/ml (100 μl/well) can bind biotinylated mouse IL17RA with a linear range of 1.28-6.4 ng/ml. -
Validations
Mouse IL17RA / IL17R / CD217 Protein (His Tag) SDS-PAGE
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