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Product Name
Integrin beta-3 antibody
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Description
Integrin beta-3 Rabbit Polyclonal antibody. Positive WB detected in human placenta tissue. Positive IHC detected in human testis tissue. Observed molecular weight by Western-blot: 140 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CD61 antibody; GP3A antibody; GPIIIa antibody; Integrin beta 3 antibody; ITGB3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_000212). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:111863(ITGB3 antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human testis using Catalog No:111863(ITGB3 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human testis using Catalog No:111863(ITGB3 antibody) at dilution of 1:50 (under 40x lens)
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Background
CD61, also named as CD61,ITGB3 and GPIIIa, is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. CD61 recognize the sequence R-G-D in a wide array of ligands and the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation CD61 brings about platelet/platelet interaction through binding of soluble fibrinogen which leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
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References
- Zhang MZ, Li C, Fang BY. High transfection efficiency of quantum dot-antisense oligonucleotide nanoparticles in cancer cells through dual-receptor synergistic targeting. Nanotechnology. 25(25):255102. 2014.
- Shi J, Jin Z, Liu X. PET imaging of neovascularization with (68)Ga-3PRGD2 for assessing tumor early response to Endostar antiangiogenic therapy. Molecular pharmaceutics. 11(11):3915-22. 2014.
- Jiang J, Sun A, Wang Y, Deng Y. Increased expression of Talin1 in the eutopic and ectopic endometria of women with adenomyosis. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2016.
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