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Integrin alpha-3 antibody

Cat.#: 107351

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Special Price 239.0 USD

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Product Information

  • Product Name
    Integrin alpha-3 antibody
  • Documents
  • Description
    Integrin alpha-3 Mouse Monoclonal antibody. Positive WB detected in PC-3 cells. Positive FC detected in A549 cells. Observed molecular weight by Western-blot: 120 kDa
  • Tested applications
    ELISA, WB, FC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    CD49C antibody; FLJ34631 antibody; FLJ34704 antibody; FRP 2 antibody; Galactoprotein B3 antibody; GAP B3 antibody; GAPB3 antibody; Integrin alpha 3 antibody; ITGA3 antibody; MSK18 antibody; VCA 2 antibody; VL3A antibody; VLA 3 subunit alpha antibody; VLA3a antibody
  • Isotype
    Mouse IgG2a
  • Preparation
    This antibody was obtained by immunization of Integrin alpha-3 recombinant protein (Accession Number: NM_002204). Purification method: Protein A purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

  • Validations

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:107351(ITGA3 antibody) at dilution of 1:1000

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:107351(ITGA3 antibody) at dilution of 1:1000

    1X10^6 A549 cells were stained with 0.2ug Integrin alpha-3 antibody (Catalog No:107351, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L) with dilution 1:1500.

    1X10^6 A549 cells were stained with 0.2ug Integrin alpha-3 antibody (Catalog No:107351, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L) with dilution 1:1500.

  • Background
    ITGA3, also named as MSK18, CD49c, GAPB3 and FRP-2, belongs to the integrin alpha chain family. It is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. ITGA3 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. ITGA3 is highly concentrated in epithelial cells where it strongly adheres to Laminin-5 and Laminin-5 induced rapid adhesion can be blocked by antibodies against the alpha-3 integrin subunit. It can be cleaved into heavy chain(840aa) and light chain(176aa). This antibody can recognize the heavy chain.
  • References
    • Ren Y, Hao P, Law SK, Sze SK. Hypoxia-induced changes to integrin α 3 glycosylation facilitate invasion in epidermoid carcinoma cell line A431. Molecular & cellular proteomics : MCP. 13(11):3126-37. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"