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Human IMP1 / IMPA1 (His Tag) recombinant protein

Cat.#: 501872

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Product Information

  • Product Name
    Human IMP1 / IMPA1 (His Tag) recombinant protein
  • Documents
  • Description
    E3 ubiquitin-protein ligase XIAP / BIRC4, also known as inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. XIAP / BIRC4 functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. XIAP / BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this encoding gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Thought to be the most potent apoptosis suppressor, XIAP / BIRC4, directly binds and inhibits caspases -3, -7 and -9. Survivin, which also binds to several caspases, is up-regulated in a many tumour cell types. Defects in XIAP / BIRC4 are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2). XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
  • Protein name
    Inositol monophosphatase 1
  • Protein short names
    RP23-207E14.3; MIHA; ILP1; XLP2; AIPA; XIAP; HIAP3; MXIAP; ILP-1; BIRC4; IAP-3; IAP3; API3; RP1-315G1.5; 1110015C02RIK; HIAP-3
  • Uniprot ID
    P29218
  • Gene Name
    IMPA1; IMPA
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human IMPA1 (P29218-1) (Met1-Asp277) was expressed with a polyhistidine tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human IMPA1 consists of 295 amino acids and predicts a molecular mass of 32.4 KDa. It migrates as an approximately 32 KDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Validations

    Human IMP1 / IMPA1 Protein (His Tag) SDS-PAGE

    Human IMP1 / IMPA1 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"