IL12RB1 antibody

IL12RB1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

IL12RB1 Rabbit Polyclonal antibody. Positive WB detected in K-562 cells. Observed molecular weight by Western-blot: 100kd

ELISA, WB

Human; other species not tested.

CD212 antibody; IL 12 receptor beta component antibody; IL 12 receptor subunit beta 1 antibody; IL 12R beta 1 antibody; IL 12R BETA1 antibody; IL 12R subunit beta 1 antibody; IL 12RB1 antibody; IL12R antibody; IL12RB antibody; IL12RB1 antibody

Rabbit IgG

This antibody was obtained by immunization of IL12RB1 recombinant protein (Accession Number: NM_153701). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

IL12RB1, also named as Interleukin-12 receptor subunit beta-1 or CD212, is a 662 amino acid protein, which contains 5 fibronectin type-III domains and belongs to the type I cytokine receptor family. Type 2 subfamily. IL12RB1 localizes in the membrane and functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

• Ford NR, Miller HE, Reeme AE. Inflammatory signals direct expression of human IL12RB1 into multiple distinct isoforms. Journal of immunology (Baltimore, Md. : 1950). 189(9):4684-94. 2012.