Human TRA-1-60 Recombinant protein (His tag)

Human TRA-1-60 Recombinant protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {PubMed:17616675, PubMed:18456258}.

Podocalyxin

PCLP; PCLP1

O00592

PODXL; PCLP; PCLP1

E. coli

A DNA sequence encoding the human PODXL (NP_005388.2) 23-428 aa was fused with the polyhistidine tag

Human

Not tested.