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Product Name
Human RXRA Recombinant protein (GST tag)
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Description
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. {PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:20215566}.
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Protein name
Retinoic acid receptor RXR-alpha
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Protein short names
NR2B1
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Uniprot ID
Q6P3U7
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Gene Name
RXRA; NR2B1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human RXRA (NP_002948.1) 113-462 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human RXRA SDS-PAGE
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