-
Product Name
Human NEDD8 (His tag) recombinant protein
- Documents
-
Description
Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation.
-
Protein name
neural precursor cell expressed, developmentally down-regulated 8(NEDD8)
-
Uniprot ID
Q15843
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
A DNA sequence encoding the Human NEDD8 Met1-Gly76 is expressed with a 6His, SUMO tag at the N-terminus.
-
Protein Species
Human
-
Purity
>95% as determined by SDS-PAGE.
-
Validations
Human NEDD8 (His tag) recombinant protein
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"