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Product Name
Human MARK1 Recombinant protein (GST tag)
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Description
Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {PubMed:11433294, PubMed:17573348}.
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Protein name
Serine/threonine-protein kinase MARK1
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Protein short names
KIAA1477; MARK
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Uniprot ID
Q9P0L2
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Gene Name
MARK1; KIAA1477; MARK
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human MARK1 (NP_061120.3) 506-611 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human MARK1 SDS-PAGE
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