Human IL36RN/FIL1D/IL1F5 recombinant protein

Cat.#: 518302

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Product Information

  • Product Name
    Human IL36RN/FIL1D/IL1F5 recombinant protein
  • Documents
  • Description
    Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family). IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9). Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence identity.
  • Protein name
    interleukin 36 receptor antagonist(IL36RN)
  • Protein short names
    FIL1D; IL1F5; IL1HY1; IL1L1; IL1RP3; UNQ1896; PRO4342
  • Uniprot ID
    Q9UBH0
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human IL36RN/FIL1D/IL1F5 Met1-Asp155 is expressed.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human IL36RN/FIL1D/IL1F5 recombinant protein

    Human IL36RN/FIL1D/IL1F5 recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"