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Product Name
Human GRB2/ASH (His tag) recombinant protein
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Description
As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK. probably via the concerted action of both its SH2 and SH3 domains.
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Protein name
growth factor receptor bound protein 2(GRB2)
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Protein short names
ASH
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Uniprot ID
P62993
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human GRB2/ASH Met1-Val217 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human GRB2/ASH (His tag) recombinant protein
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