Human ENPP1 Recombinant protein (GST tag)

Human ENPP1 Recombinant protein (GST tag)

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By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function. {PubMed:10615944, PubMed:8001561}.

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

M6S1; NPPS; PC1; PDNP1

P22413

ENPP1; M6S1; NPPS; PC1; PDNP1

E. coli

A DNA sequence encoding the human ENPP1 (NP_006199.2) 575-925 aa was fused with the N-terminal GST tag

Human

Not tested.