HDAC3-specific antibody

HDAC3-specific antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

HDAC3-specific Rabbit Polyclonal antibody. Positive WB detected in HL-60 cells, human stomach tissue, U-937 cells. Observed molecular weight by Western-blot: 50kd

ELISA, WB

human, mouse, rat; other species not tested.

HDAC3 antibody; histone deacetylase 3 antibody; RPD3 antibody; RPD3 2 antibody; HD3 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_003883). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the (-amino groups of lysines located near the amino termini of core histone proteins. At least 4 classes of HDAC were identified. HDAC3 is a class I HDAC. HDAC3 has histone deacetylase activity and may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. HDAC3 can also down-regulate p53 function and thus modulate cell growth and apoptosis. The gene encoding HDAC3 is regarded as a potential tumor suppressor gene. This antibody is a rabbit polyclonal antibody raised against a peptide mapping within human HDAC3. This antibody is specific to HDAC3, and will not cross react with other HDACs.