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Product Name
HCN2 antibody
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Description
HCN2 Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, Jurkat cells. Positive IHC detected in human heart tissue, human brain tissue. Observed molecular weight by Western-blot: 97-110 kDa
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Tested applications
ELISA, WB, IP, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
HAC 1 antibody; HCN2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_001194). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:111285(HCN2 antibody) at dilution of 1:800
Immunohistochemical of paraffin-embedded human heart using Catalog No:111285(HCN2 antibody) at dilution of 1:50 (under 40x lens)
IP Result of anti-HCN2 (IP:Catalog No:111285, 4ug; Detection:Catalog No:111285 1:800) with mouse brain tissue lysate 4000ug.
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Background
HCN2, also named as BCNG2, belongs to the potassium channel HCN family. It hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). HCN2 produces a large instantaneous current. It is activated by cAMP. HCN2 is modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages. This antibody is specific to HCN2.
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