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Product Name
HBP1 antibody
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Description
HBP1 Rabbit Polyclonal antibody. Positive WB detected in human brain tissue. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 58 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
FLJ16340 antibody; HBP1 antibody; HMG box containing protein 1 antibody; HMG box transcription factor 1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of HBP1 recombinant protein (Accession Number: XM_017011967). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:111271(HBP1 antibody) at dilution of 1:1000
IP Result of anti-HBP1 (IP:Catalog No:111271, 4ug; Detection:Catalog No:111271 1:500) with mouse brain tissue lysate 4000ug.
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Background
HMG-box protein 1 (HBP1) is a transcriptional repressor, and has a role in cell cycle progression and tumor suppression. Also it's a repressor of the cyclin D1 gene and inhibits the Wnt signaling pathway. Interaction with RB1 enhances it's binding to the H1F0 promoter . Disrupts the interaction between DNA and TCF4. This is a rabbit polyclonal antibody raised against part of C-terminus of HBP1 of human origin.
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References
- Pan K, Chen Y, Roth M. HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence. Molecular and cellular biology. 33(5):887-903. 2013.
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