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Product Name
GNG2 antibody
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Description
GNG2 Rabbit Polyclonal antibody. Positive WB detected in mouse testis tissue, mouse brain tissue. Observed molecular weight by Western-blot: 8 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
G gamma I antibody; GNG2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of GNG2 recombinant protein (Accession Number: XM_017021377). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
mouse testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:111001(GNG2 antibody) at dilution of 1:400
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Background
Gγ2 subunit (Gng2/GNG2) is one of subunits of the Gβγ-dimer composing heterotrimeric G protein with a Gα-subunit. Heterotrimeric G protein has been reported to be involved in various biological activities including cell proliferation, differentiation, invasion and angiogenesis. It is expressed in a range of foetal tissues as well as adult testis, adrenal gland, brain, white blood cells and lung.
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References
- Yajima I, Kumasaka MY, Yamanoshita O. GNG2 inhibits invasion of human malignant melanoma cells with decreased FAK activity. American journal of cancer research. 4(2):182-8. 2014.
- Yajima I, Kumasaka MY, Naito Y. Reduced GNG2 expression levels in mouse malignant melanomas and human melanoma cell lines. American journal of cancer research. 2(3):322-9. 2012.
- Yajima I, Kumasaka MY, Tamura H, Ohgami N, Kato M. Functional analysis of GNG2 in human malignant melanoma cells. Journal of dermatological science. 68(3):172-8. 2012.
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