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Product Name
GIMAP5 antibody
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Description
GIMAP5 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, U-937 cells. Positive IHC detected in human lymphoma tissue. Observed molecular weight by Western-blot: 45-50 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
FLJ11296 antibody; GIMAP5 antibody; GTPase IMAP family member 5 antibody; GTPase antibody; IMAP family member 5 antibody; hIAN5 antibody; HIMAP3 antibody; IAN 5 antibody; IAN4 antibody; IAN4L1 antibody; IAN5 antibody; IMAP3 antibody; Immunity assOCiated protein 3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of GIMAP5 recombinant protein (Accession Number: NM_018384). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:110974(GIMAP5 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:110974(GIMAP5 antibody) at dilution of 1:50 (under 10x lens)
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Background
GIMAP5 gene encodes immunity-associated nucleotide 5 protein (IAN5) belonging to GTPase immune-associated protein subfamily. GIMAP5 is widely expressed with high levels in lymph node and spleen. The loss of Gimap5 (GTPase of the 5) gene function is the underlying cause of lymphopenia and autoimmune diabetes in the BioBreeding (BB) rat. Mouse gimap5 is necessary for the survival of peripheral T cells, NK/NKT-cell development, hematopoietic progenitor cell survival and the maintenance of normal liver function. GIMAP5 may regulate T lymphocyte survival by mechanisms that operate upstream of mitochondria.
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References
- Chadwick N, Zeef L, Portillo V. Identification of novel Notch target genes in T cell leukaemia. Molecular cancer. 8:35. 2009.
- Chadwick N, Zeef L, Portillo V. Notch protection against apoptosis in T-ALL cells mediated by GIMAP5. Blood cells, molecules & diseases. 45(3):201-9. 2010.
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