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Product Name
GGPS1 antibody
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Description
GGPS1 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, human heart tissue, human placenta tissue, human testis tissue, mouse bladder tissue. Positive IP detected in mouse brain tissue. Positive IHC detected in human kidney tissue, human liver tissue, human testis tissue. Observed molecular weight by Western-blot: 35 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
GGPP synthase antibody; GGPPS antibody; GGPPS1 antibody; GGPPSase antibody; GGPS1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of GGPS1 recombinant protein (Accession Number: NM_004837). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:110960(GGPS1 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human kidney using Catalog No:110960(GGPS1 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human kidney using Catalog No:110960(GGPS1 antibody) at dilution of 1:100 (under 40x lens)
IP Result of anti-GGPS1 (IP:Catalog No:110960, 4ug; Detection:Catalog No:110960 1:500) with mouse brain tissue lysate 2640ug.
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Background
GGPS1(Geranylgeranyl pyrophosphate synthase) belongs to the FPP/GGPP synthase family and catalyzes the synthesis of GGPP, an important molecule responsible for the C20-prenylation of protein and for the regulation of a nuclear hormone receptor. GGPP synthase puri¢ed from bovine brain is reported to be a homo-oligomer (150-195 kDa) with a molecular mass of 37.5 kDa for the monomer.This is consistent with the calculated molecular mass (35 kDa) of mouse and human GGPP synthases (PMID:10101267).
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References
- Yu DC, Liu J, Chen J. GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis. BMC cancer. 14:248. 2014.
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