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Product Name
GFRA2 antibody
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Description
GFRA2 Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, mouse brain tissue. Positive IHC detected in human liver tissue. Observed molecular weight by Western-blot: 34-40kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
GDNF family receptor alpha 2 antibody; GDNF receptor alpha 2 antibody; GDNF receptor beta antibody; GDNFR alpha 2 antibody; GDNFR beta antibody; GDNFRB antibody; GFR alpha 2 antibody; GFRA2 antibody; Neurturin receptor alpha antibody; NRTNR ALPHA antibody; NTNR alpha antibody; NTNRA antibody; RET ligand 2 antibody; RETL2 antibody; TRNR2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of GFRA2 recombinant protein (Accession Number: XM_011544484). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
WB result of Catalog No:110954(GFRA2 antibody).
HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:110954(GFRA2 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human liver using Catalog No:110954(GFRA2 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver using Catalog No:110954(GFRA2 antibody) at dilution of 1:50 (under 40x lens)
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Background
GFRA2, also named as GDNFRB, RETL2 and TRNR2, belongs to the GDNFR family. It is a receptor for neurturin. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It is a potent survival factor for central dopaminergic neurons, motor neurons, and several other populations of neurons in the central and peripheral nervous systems. The GDNF signal is mediated by a complex of the receptor tyrosine kinase RET and a glycosylphosphatidylinositol (GPI)-linked protein, GDNFRA. GFRA2 has three isoforms with MW 34-36 kDa, 39-41 kDa and 50-52 kDa. This antibody recognizes all the three isoforms.
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