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Product Name
GCK antibody
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Description
GCK Rabbit Polyclonal antibody. Positive WB detected in mouse liver tissue. Observed molecular weight by Western-blot: 52 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
GCK antibody; GLK antibody; Glucokinase antibody; glucokinase (hexokinase 4) antibody; Hexokinase 4 antibody; Hexokinase D antibody; Hexokinase type IV antibody; HHF3 antibody; HK IV antibody; HK4 antibody; HKIV antibody; HXKP antibody; MODY2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of GCK recombinant protein (Accession Number: NM_000162). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:110904(GCK Antibody) at dilution of 1:600
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Background
Glucokinase (GCK) is a structurally and functionally unique member of hexokinase family. It is expressed only in mammalian liver and pancreatic islet beta cells. Because of its unique functional characteristics, the enzyme plays an important regulatory role in glucose metabolism. The rate of glucose metabolism in liver and pancreas is a function of the activity of the enzyme(PMID:1740341). Defects in GCK are the cause of maturity-onset diabetes of the young type 2 (MODY2) and familial hyperinsulinemic hypoglycemia type 3 (HHF3). It has 3 isoforms produced by alternative splicing with the same molecular mass of 52 kDa.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"