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Product Name
GAA antibody
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Description
GAA Rabbit Polyclonal antibody. Positive IP detected in mouse liver tissue. Positive WB detected in human heart tissue. Positive IHC detected in human pancreas cancer tissue. Observed molecular weight by Western-blot: 70-76 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Acid maltase antibody; Aglucosidase alfa antibody; GAA antibody; glucosidase antibody; alpha; acid antibody; LYAG antibody; Lysosomal alpha glucosidase antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of GAA recombinant protein (Accession Number: XM_047435719). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:110767(GAA antibody) at dilution of 1:600
Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:110767(GAA antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:110767(GAA antibody) at dilution of 1:50 (under 40x lens)
IP Result of anti-GAA (IP:Catalog No:110767, 4ug; Detection:Catalog No:110767 1:600) with mouse liver tissue lysate 4000ug.
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Background
GAA(Alpha-1,4-glucosidase) is a lysosomal enzyme involved in the degradation of glycogen within cellular vacuoles. After translation, GAA undergoes proteolytic processing to form two lengths of lysosomal a-glucosidase, and both N-terminal and C-terminal processing occur. The full sequence can be further processed into a mature form. The 105 kDa GAA can be cleaved into 70 kDa or 76 kDa form.
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