FZD4 Polyclonal Antibody

Cat.#: 162451

Special Price 174.2 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    FZD4 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to FZD4
  • Tested applications
    IF
  • Species reactivity
    Human
  • Alternative names
    FZD4 antibody; CD344 antibody; EVR1 antibody; FEVR antibody; FZD4S antibody; Fz-4 antibody; Fz4 antibody; FzE4 antibody; GPCR antibody; hFz4 antibody; frizzled-4 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 37-222 of human FZD4 (NP_036325.2).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    IF 1:50 - 1:200
  • Validations

    Immunofluorescence - FZD4 Polyclonal Antibody

    Immunofluorescence - FZD4 Polyclonal Antibody

    Immunofluorescence analysis of U2OS cells using FZD4 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

  • Background
    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"