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Mouse Frizzled-10/FZD10 (CD350) (Fc Tag) recombinant protein

Cat.#: 501014

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Product Information

  • Product Name
    Mouse Frizzled-10/FZD10 (CD350) (Fc Tag) recombinant protein
  • Documents
  • Description
    Mouse Frizzled-10, also known as Fz-10, CD350 and FZD10, is a multi-pass membrane protein which belongs to the G-protein coupled receptor Fz/Smo family. Frizzled-10 / FZD10 is abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. It is weakly expressed in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate. Frizzled-10 / FZD10 is a receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Frizzled-10 / FZD10 may also be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
  • Protein name
    Frizzled homolog 10 (Drosophila)
  • Protein short names
    FZ-10; HFZ10; FZD10; FZ10; CD350; FRIZZLED-10; FZ-1; FZE7
  • Uniprot ID
    Q8BKG4
  • Gene Name
    Fzd10; mCG_51280
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the N-terminal segment of mouse FZD10 (NP_780493.1) (Met 1-Gly 162) was fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse FZD10/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 382 amino acids and has a predicted molecular mass of 43 kDa. As a result of glycosylation, the apparent molecular mass of rm FZD10/Fc monomer is approximately 52 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Mouse Frizzled-10 / FZD10 Protein (Fc Tag) SDS-PAGE

    Mouse Frizzled-10 / FZD10 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"