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Product Name
FOXO4 antibody
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Description
FOXO4 Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive WB detected in human heart tissue, mouse heart tissue. Observed molecular weight by Western-blot: 45-48kd
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Tested applications
ELISA, WB, IF
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
AFX antibody; AFX1 antibody; forkhead box O4 antibody; Forkhead box protein O4 antibody; FOXO4 antibody; MLLT7 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_005938). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IF: 1:10-1:100
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Validations
human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:110705(FOXO4 antibody) at dilution of 1:800
Immunofluorescent analysis of HepG2 cells, using FOXO4 antibody Catalog No:110705 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
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Background
FOXO4, also named as AFX, AFX1 and MLLT7, is a transcription factor which involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1.FOXO down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is involved in negative regulation of the cell cycle. A chromosomal aberration involving FOXO4 is found in acute leukemias. The antiboay can recognize isoform 1 and isoform Zeta of FOXO4.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"