FOXC2 antibody

FOXC2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

FOXC2 Rabbit Polyclonal antibody. Positive WB detected in A375 cells, A431 cells, rat spleen tissue. Observed molecular weight by Western-blot: 56 kDa

ELISA, WB

Human, Rat, Mouse; other species not tested.

FKHL14 antibody; Forkhead box protein C2 antibody; FOXC2 antibody; Mesenchyme fork head protein 1 antibody; MFH 1 antibody; MFH 1 protein antibody; MFH1 antibody; Transcription factor FKH 14 antibody

Rabbit IgG

This antibody was obtained by immunization of FOXC2 recombinant protein (Accession Number: NM_005251). Purification method: Antigen Affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.Defects in FOXC2 are the cause of lymphedema hereditary type 2 (LMPH2) [MIM:153200]; also known as Meige lymphedema. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections, and physical impairment. Defects in FOXC2 are a cause of lymphedema-yellow nails (LYYN) [MIM:153300]. LYYN is characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities. Defects in FOXC2 are a cause of lymphedema-distichiasis (LYD) [MIM:153400]. LYD is characterized by primary limb lymphedema usually starting at puberty (but in some cases later or at birth) and associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices).This antibody specifically recognizes the 56 kDa FOXC2 protein.

• Wang P, Cheng H, Wu J, Yan A, Zhang L. STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential. Acta biochimica et biophysica Sinica. 47(3):214-23. 2015.