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Product Name
FKBP5 antibody
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Description
FKBP5 Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, HEK-293 cells, mouse thymus tissue. Positive IP detected in K-562 cells. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 51 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
51 kDa FK506 binding protein antibody; 51 kDa FKBP antibody; AIG6 antibody; Androgen regulated protein 6 antibody; FF1 antigen antibody; FK506 binding protein 5 antibody; FKBP 5 antibody; FKBP 51 antibody; FKBP5 antibody; FKBP51 antibody; FKBP54 antibody; HSP90 binding immunophilin antibody; P54 antibody; PPIase antibody; PPIase FKBP5 antibody; Ptg 10 antibody; Rotamase antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of FKBP5 recombinant protein (Accession Number: NM_001145775). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:500-1:5000
IHC: 1:20-1:200
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Validations
K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:110675(FKBP5 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:110675(FKBP5 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:110675(FKBP5 antibody) at dilution of 1:50 (under 40x lens)
IP Result of anti-FKBP5 (IP:Catalog No:110675, 3ug; Detection:Catalog No:110675 1:1000) with K-562 cells lysate 1500ug.
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Background
FKBP5(Peptidyl-prolyl cis-trans isomerase FKBP5 ) interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Unlike the predominant T-cell expression of the mouse protein, FKBP5 is expressed as a 51-kD protein in a variety of tissues but not in brain, colon, or lung(PMID: 9125197).
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References
- Hill R, Li Y, Tran LM. Cell intrinsic role of COX-2 in pancreatic cancer development. Molecular cancer therapeutics. 11(10):2127-37. 2012.
- Martinez NJ, Chang HM, Borrajo Jde R, Gregory RI. The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly. RNA (New York, N.Y.). 19(11):1583-93. 2013.
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