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Fibrinogen gamma chain antibody

Cat.#: 110657

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Product Information

  • Product Name
    Fibrinogen gamma chain antibody
  • Documents
  • Description
    Fibrinogen gamma chain Rabbit Polyclonal antibody. Positive WB detected in human spleen tissue, human liver tissue. Positive IHC detected in human hepat℃irrhosis tissue. Observed molecular weight by Western-blot: 52 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    FGG antibody; fibrinogen gamma chain antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Fibrinogen gamma chain recombinant protein (Accession Number: NM_000509). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    human spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:110657(FGG antibody) at dilution of 1:400

    human spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:110657(FGG antibody) at dilution of 1:400

    Immunohistochemistry of paraffin-embedded human hepatocirrhosis tissue slide using Catalog No:110657(FGG Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human hepatocirrhosis tissue slide using Catalog No:110657(FGG Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human hepatocirrhosis tissue slide using Catalog No:110657(FGG Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human hepatocirrhosis tissue slide using Catalog No:110657(FGG Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    Fibrinogen is a soluble plasma glycoprotein synthesized in the liver. It is composed of two sets of three structurally different subunits: alpha (FGA), beta (FGB), gamma (FGG). Fibrinogen is converted by thrombin into fibrin during blood coagulation. Fibrinogen and fibrin play overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, the inflammatory response, wound healing, and neoplasia (PMID: 16102057). FGG is the gamma chain of fibrinogen. Mutations in the gene of FGG lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.
  • References
    • Krishnamoorthy A, Ajay AK, Hoffmann D. Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury. Blood. 118(7):1934-42. 2011.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"