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Product Name
Fibrinogen gamma chain antibody
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Description
Fibrinogen gamma chain Mouse Monoclonal antibody. Positive IHC detected in human liver tissue, human kidney tissue. Positive IF detected in L02 cells. Positive WB detected in L02 cells. Observed molecular weight by Western-blot: 52 kDa
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Tested applications
ELISA, WB, IHC, IF
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Species reactivity
Human; other species not tested.
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Alternative names
FGG antibody; fibrinogen gamma chain antibody
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Isotype
Mouse IgM
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Preparation
This antibody was obtained by immunization of Fibrinogen gamma chain recombinant protein (Accession Number: NM_000509). Purification method: Thiophilic Affinity Chromatography.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:20-1:200
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Validations
L02 cells were subjected to SDS PAGE followed by western blot with Catalog No:107212(FGG Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver tissue slide using Catalog No:107212(FGG Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human liver tissue slide using Catalog No:107212(FGG Antibody) at dilution of 1:50 (under 40x lens)
Immunofluorescent analysis of L02 cells using Catalog No:107212(FGG Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L)
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Background
Fibrinogen is a soluble plasma glycoprotein synthesized in the liver. It is composed of two sets of three structurally different subunits: alpha (FGA), beta (FGB), gamma (FGG). Fibrinogen is converted by thrombin into fibrin during blood coagulation. Fibrinogen and fibrin play overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, the inflammatory response, wound healing, and neoplasia (PMID: 16102057). FGG is the gamma chain of fibrinogen. Mutations in the gene of FGG lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.
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