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Product Name
FGFR1OP antibody
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Description
FGFR1OP Rabbit Polyclonal antibody. Positive WB detected in mouse heart tissue. Positive IHC detected in human lymphoma tissue. Observed molecular weight by Western-blot: 50kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
FGFR1 oncogene partner antibody; FGFR1OP antibody; FOP antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of FGFR1OP recombinant protein (Accession Number: NM_194429). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
mouse heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:110640(FGFR1OP antibody) at dilution of 1:800
Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:110640(FGFR1OP antibody) at dilution of 1:50 (under 10x lens)
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Background
The fibroblast growth factor receptor 1 oncogene partner (FGFR1OP), FOP, is a centrosomal protein that is involved in the anchoring of microtubules to subcellular structures. Three isoforms have been produced by alternative splicing. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma and progresses to acute myeloid leukemia.
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References
- Korzeniewski N, Cuevas R, Duensing A, Duensing S. Daughter centriole elongation is controlled by proteolysis. Molecular biology of the cell. 21(22):3942-51. 2010.
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