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FBXW11 antibody

Cat.#: 110561

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Product Information

  • Product Name
    FBXW11 antibody
  • Documents
  • Description
    FBXW11 Rabbit Polyclonal antibody. Positive IHC detected in human stomach cancer tissue. Positive WB detected in SGC-7901 cells, human stomach tissue, mouse stomach tissue. Positive IP detected in mouse stomach tissue. Observed molecular weight by Western-blot: 61 kDa
  • Tested applications
    ELISA, WB, IHC, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    BTRC2 antibody; BTRCP2 antibody; Fbw11 antibody; FBW1B antibody; FBXW11 antibody; FBXW1B antibody; Homologous to Slimb protein antibody; Hos antibody; KIAA0696 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of FBXW11 recombinant protein (Accession Number: NM_033644). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:1000-1:10000

    IP: 1:200-1:2000

    IHC: 1:50-1:500

  • Validations

    SGC-7901 cells were subjected to SDS PAGE followed by western blot with Catalog No:110561(FBXW11 antibody) at dilution of 1:2000

    SGC-7901 cells were subjected to SDS PAGE followed by western blot with Catalog No:110561(FBXW11 antibody) at dilution of 1:2000

    IP Result of anti-FBXW11 (IP:Catalog No:110561, 4ug; Detection:Catalog No:110561 1:600) with mouse stomach tissue lysate 4000ug.

    IP Result of anti-FBXW11 (IP:Catalog No:110561, 4ug; Detection:Catalog No:110561 1:600) with mouse stomach tissue lysate 4000ug.

    Immunohistochemistry of paraffin-embedded human stomach cancer tissue slide using Catalog No:110561(FBXW11 Antibody) at dilution of 1:100 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human stomach cancer tissue slide using Catalog No:110561(FBXW11 Antibody) at dilution of 1:100 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human stomach cancer tissue slide using Catalog No:110561(FBXW11 Antibody) at dilution of 1:100 (under 40x lens).

    Immunohistochemistry of paraffin-embedded human stomach cancer tissue slide using Catalog No:110561(FBXW11 Antibody) at dilution of 1:100 (under 40x lens).

  • Background
    FBXW11(F-box/WD repeat-containing protein 11) is also named as BTRCP2, FBW1B, FBXW1B, KIAA0696,HOS.It mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription.It has 3 isoforms produced by alternative splicing.
  • References
    • Chen H, Ma H, Inuzuka H. DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase. Molecular and cellular biology. 33(6):1139-48. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"