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FAM3C antibody

Cat.#: 110586

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Special Price 239.0 USD

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Product Information

  • Product Name
    FAM3C antibody
  • Documents
  • Description
    FAM3C Rabbit Polyclonal antibody. Positive IHC detected in human pancreas. Positive WB detected in human brain tissue, HEK-293 cells, human heart tissue. Observed molecular weight by Western-blot: 25kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    human, mouse, rat; other species not tested.
  • Alternative names
    FAM3C antibody; Protein FAM3C antibody; GS3786 antibody; Interleukin like EMT inducer antibody; ILEI antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of FAM3C recombinant protein (Accession Number: XM_047419774). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:110586(FAM3C antibody) at dilution of 1:500

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:110586(FAM3C antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human pancreas using Catalog No:110586(FAM3C antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human pancreas using Catalog No:110586(FAM3C antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human pancreas using Catalog No:110586(FAM3C antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human pancreas using Catalog No:110586(FAM3C antibody) at dilution of 1:50 (under 40x lens)

  • Background
    FAM3C, also known as ILEI, is a secreted protein belonging to the cytokine-like protein family. FAM3C is a signaling cytokine with a GG domain, hydrophobic leader sequence and an N-terminal signal peptide. A change in expression of this protein has been noted in pancreatic cancer-derived cells. FAM3C has been involved in the epithelial to mesenchymal transition, and retinal laminar formation processes in vertebrates. Also, FAM3C may play an important role in inner ear development and thus be involved in cell differentiation and proliferation during inner ear embryogenesis.
  • References
    • Loei H, Tan HT, Lim TK. Mining the gastric cancer secretome: identification of GRN as a potential diagnostic marker for early gastric cancer. Journal of proteome research. 11(3):1759-72. 2012.
    • Zhu YH, Zhang B, Li M. Prognostic significance of FAM3C in esophageal squamous cell carcinoma. Diagnostic pathology. 10:192. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"