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Product Name
FAH antibody
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Description
FAH Rabbit Polyclonal antibody. Positive WB detected in mouse liver tissue, human liver tissue, rat liver tissue. Observed molecular weight by Western-blot: 40-45kd
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Beta diketonase antibody; FAA antibody; FAH antibody; Fumarylacetoacetase antibody; Fumarylacetoacetate hydrolase antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of FAH recombinant protein (Accession Number: NM_000137). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:110453(FAH antibody) at dilution of 1:500
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Background
FAH is also named as FAA(fumarylacetoacetase), the last enzyme in tyrosine degradation, functionally important in the liver and kidney(PMID:8473520). FAH is a metabolic enzyme catalyzing the last step of tyrosine and phenylalanine catabolism: the hydrolysis of fumarylacetoacetate into acetoacetate and fumarate. In humans, deficiency of this activity is associated with the metabolic disease hereditary tyrosinaemia type I, which is also known as hepatorenal tyrosinaemia(PMID:17768357).
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References
- Li W, Ye F, Wang D. Protein predictive signatures for lymph node metastasis of gastric cancer. International journal of cancer. 132(8):1851-9. 2013.
- Lian G, Wei C, Wang D. Protein profiling of Helicobacter pylori-associated gastric cancer. The American journal of pathology. 184(5):1343-54. 2014.
- Chen W, Ye F, Cui M. Protein marker profiling in different T classification in laryngeal squamous cell carcinoma. Head & neck. 37(3):357-65. 2015.
- Huang K, Cui M, Ye F, Li Y, Zhang D. Global profiling of the signaling network of papillary thyroid carcinoma. Life sciences. 147:9-14. 2016.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"