Factor XII antibody

Factor XII antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Factor XII Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue, human colon cancer tissue. Positive WB detected in Jurkat cells, HepG2 cells, mouse liver tissue. Observed molecular weight by Western-blot: 28 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

Coagulation factor XII antibody; F12 antibody; Factor XII antibody; HAE3 antibody; HAEX antibody; HAF antibody; Hageman factor antibody

Rabbit IgG

This antibody was obtained by immunization of Factor XII recombinant protein (Accession Number: BC012390). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Factor XII (F XII, Hageman factor) is a 80kD, single chain glycoprotein that circulates in blood as an inactive zymogen. F XII plays an important role in blood coagulation, fibrinolysis, and kinin generation. When plasma comes into contact with negatively charged surfaces such as glass, kaolin, or dextran sulfate, F XII is bound to the surface and undergoes limited proteolysis by plasma kallikrein, resulting in two active enzyme forms, ɑ-F XIIa and β-F XIIa. ɑ-F XIIa consisting of a 28kD light chain containing the protease domain, and a 52kD heavy chain containing the anionic surface-binding domain. β-F XIIa consists of two disulfide-linked chains, a 2 kD light chain and a 28 kD heavy chain containing the catalytic domain. Defects in Factor XII do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.