-
Product Name
FABP5 antibody
- Documents
-
Description
FABP5 Rabbit Polyclonal antibody. Positive IHC detected in human lung cancer. Positive WB detected in human brain tissue, A375 cells, mouse skin tissue. Observed molecular weight by Western-blot: 15kd
-
Tested applications
ELISA, WB, IHC
-
Species reactivity
Human,Mouse,Rat; other species not tested.
-
Alternative names
FABP5 antibody; PA FABP antibody; EFABP antibody; Fatty acid binding protein 5 antibody; PAFABP antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of FABP5 recombinant protein (Accession Number: NM_001444). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
-
Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:110441(FABP5 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:110441(FABP5 antibody) at dilution of 1:50 (under 10x lens)
-
Background
FABP5, also named as PA-FABP and E-FABP, belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. It is high specificity for fatty acids. FABP5 is highest affinity for C18 chain length. It may be involved in keratinocyte differentiation. FABP5 is a fatty acid-binding protein and is expressed in epidermis and endothelial cells of the microvasculature of different organs. FABP5 has also been identified as a tumor-associated antigen, which is highly expressed in various cancers. FABP5 was detected in the sera of HNSCC patients with early stage cancer. Antibodies specific for FABP5 were significantly increased in a substantial amount in patients, suggesting that FABP5 may be a potential diagnostic biomarker for HNSCC. FABP5 may serve as a biomarker for HNSCC.(PMID:19602232)
-
References
- Chen NN, Li Y, Wu ML. CRABP-II- and FABP5-independent all-trans retinoic acid resistance in COLO 16 human cutaneous squamous cancer cells. Experimental dermatology. 21(1):13-8. 2012.
- Dallaglio K, Marconi A, Truzzi F. E-FABP induces differentiation in normal human keratinocytes and modulates the differentiation process in psoriatic keratinocytes in vitro. Experimental dermatology. 22(4):255-61. 2013.
- Gericke J, Ittensohn J, Mihály J, Dubrac S, Rühl R. Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice. PloS one. 8(8):e71244. 2013.
- Xia SL, Wu ML, Li H. CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid. Oncotarget. 6(8):5889-902. 2015.
- Han J, Kioi M, Chu WS, Kasperbauer JL, Strome SE, Puri RK. Identification of potential therapeutic targets in human head & neck squamous cell carcinoma. Head & neck oncology. 1:27. 2009.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"