-
Product Name
EXOSC5 antibody
- Documents
-
Description
EXOSC5 Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, HEK-293 cells, HeLa cells, Raji cells, rat kidney tissue. Positive IHC detected in human breast cancer. Observed molecular weight by Western-blot: 28-30 kDa
-
Tested applications
ELISA, WB, IHC
-
Species reactivity
human, rat; other species not tested.
-
Alternative names
EXOSC5 antibody; p12B antibody; exosome component 5 antibody; RRP46 antibody; hRrp46p antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of EXOSC5 recombinant protein (Accession Number: NM_020158). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
-
Validations
K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:110412(EXOSC5 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:110412(EXOSC5 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:110412(EXOSC5 antibody) at dilution of 1:50 (under 40x lens)
-
Background
CML28 is a component of the human exosome, which is a multiprotein complex involved in the 3′ processing and degradation of RNA [PMID:12359762]. CML28 is a novel 28 kDa TAA identified by serological analysis of cDNA expression libraries (SEREX) screening of a chronic myeloid leukemia (CML) cDNA expression library. As a potential target for tumor-specific immunotherapy, CML28 is superior to other known TAAs characterized by its broader spectrum expression in tumor cells and stricter expression in normal tissues [PMID:16815301].
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"