ERO1LB antibody

ERO1LB antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

ERO1LB Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, mouse brain tissue, rat brain tissue. Positive IHC detected in human pancreas tissue. Observed molecular weight by Western-blot: 54kd

ELISA, WB, IHC

Human, Mouse, Rat; other species not tested.

ERO1 L beta antibody; ERO1 like beta (S. cerevisiae) antibody; ERO1 like protein beta antibody; ERO1LB antibody; Oxidoreductin 1 L beta antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_019891). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

ERO1LB is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. It acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Glutathione may be required to regulate its activity in the endoplasmic reticulum. It may be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. It is required for the folding of cell, thereby being a source of oxidative stress. This antibody has no cross reaction to ERO1L.