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Product Name
EIF2B4 antibody
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Description
EIF2B4 Rabbit Polyclonal antibody. Positive WB detected in human skeletal muscle tissue, HeLa cells, HL-60 cells, K-562 cells, MCF7 cells. Positive IHC detected in human breast cancer tissue, human testis tissue. Observed molecular weight by Western-blot: 60kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
DKFZp586J0119 antibody; EIF 2B antibody; EIF2B antibody; EIF2B4 antibody; EIF2BD antibody; EIF2Bdelta antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of EIF2B4 recombinant protein (Accession Number: NM_001034116). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with Catalog No:110184(EIF2B4 antibody) at dilution of 1:400
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:110184(EIF2B4 antibody) at dilution of 1:100 (under 10x lens)
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Background
EIF2B4 represents eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
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References
- Wortham NC, Martinez M, Gordiyenko Y, Robinson CV, Proud CG. Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(5):2225-37. 2014.
- Sidrauski C, Tsai JC, Kampmann M. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. eLife. 4:e07314. 2015.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"