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Product Name
Dysadherin antibody
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Description
Dysadherin Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue, human cervical cancer tissue. Positive WB detected in mouse small intestine tissue, human placenta tissue. Observed molecular weight by Western-blot: 24 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
dysad antibody; Dysadherin antibody; FXYD5 antibody; HSPC113 antibody; IWU 1 antibody; IWU1 antibody; KCT1 antibody; OIT2 antibody; PRO6241 antibody; RIC antibody; UNQ2561/PRO6241 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Dysadherin recombinant protein (Accession Number: NM_014164). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
mouse small intestine tissue were subjected to SDS PAGE followed by western blot with Catalog No:110146(FXYD5 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human kidney using Catalog No:110146(FXYD5 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human kidney using Catalog No:110146(FXYD5 antibody) at dilution of 1:50 (under 40x lens)
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Background
Dysadherin, also known as FXYD5 (FXYD domain containing ion transport regulator 5), is a cancer-associated cell membrane glycoprotein which belongs to the FXYD family. The FXYD family, which contains seven members, are tissue specific regulators of the Na,K-ATPase. Dysadherin is involved in down-regulation of E-cadherin, which plays important roles in tumor development and metastasis. It is present in spleen, lung, skeletal muscle, and testis. Increased expression of dysadherin has been associated with increased cell motility and metastatic potential.
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