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Product Name
DSE antibody
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Description
DSE Rabbit Polyclonal antibody. Positive IHC detected in human liver cancer tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
dermatan sulfate epimerase antibody; DS epimerase antibody; DSE antibody; DSEPI antibody; SART 2 antibody; SART2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of DSE recombinant protein (Accession Number: NM_013352). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:110025(DSE antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:110025(DSE antibody) at dilution of 1:50 (under 40x lens)
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Background
DSE, also named as SART2 and DSEPI, is an enzyme that converts D-glucuronic acid to L-iduronic acid residues in dermatan sulphate biosynthesis. It is also identified to be a tumour-associated antigen. DSE is recognized by cytotoxic T cells (CTLs) and its enhanced expression in many cancers has been reported. DSE is a potential candidate for a tumour antigen with immunogenicity.
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References
- Mizukoshi E, Fushimi K, Arai K, Yamashita T, Honda M, Kaneko S. Expression of chondroitin-glucuronate C5-epimerase and cellular immune responses in patients with hepatocellular carcinoma. Liver international : official journal of the International Association for the Study of the Liver. 32(10):1516-26. 2012.
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