Drosha antibody

Drosha antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Drosha Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells, HeLa cells, HepG2 cells. Observed molecular weight by Western-blot: 90 kDa,151 kDa

ELISA, WB

Human,Mouse,Rat; other species not tested.

DROSHA antibody; ETOHI2 antibody; HSA242976 antibody; p241 antibody; RANSE3L antibody; Ribonuclease 3 antibody; Ribonuclease III antibody; ribonuclease type III antibody; nuclear antibody; RN3 antibody; RNase III antibody; RNASE3L antibody; RNASEN antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_013235). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

DROSHA, also named as RN3, RNASE3L, P241 and RNASEN, is double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. It is a component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, RNASEN/DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. RNASEN is involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. And it is involved in the formation of GW bodies. The antibody is specific to DROSHA. DROSHA/RNASEN has some transcription forms with MW 160kd, 151kd, 138kd and 90kd.