DR1 antibody

DR1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

DR1 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer. Positive WB detected in mouse testis tissue, PC-3 cells. Observed molecular weight by Western-blot: 19-20kd

ELISA, WB, IHC

human, mouse, rat; other species not tested.

DR1 antibody; NC2 BETA antibody; NC2 antibody; Negative cofactor 2 beta antibody; Protein Dr1 antibody

Rabbit IgG

This antibody was obtained by immunization of DR1 recombinant protein (Accession Number: NM_001938). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Down-regulator of transcription 1, TATA box-binding protein (TBP)-binding (negative cofactor 2) is a TBP associated phosphoprotein that represses both basal and activated levels of TBP transcription. DR1 is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. DR1 contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

• Guelman S, Kozuka K, Mao Y. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Molecular and cellular biology. 29(5):1176-88. 2009.