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Product Name
DPYS antibody
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Description
DPYS Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells. Positive IHC detected in human liver tissue. Observed molecular weight by Western-blot: 57kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
DHP antibody; DHPase antibody; Dihydropyrimidinase antibody; DPYS antibody; Hydantoinase antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of DPYS recombinant protein (Accession Number: NM_001385). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:110009(DPYS antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human liver using Catalog No:110009(DPYS antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver using Catalog No:110009(DPYS antibody) at dilution of 1:50 (under 40x lens)
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Background
DPYS(Dihydropyrimidinase)also known as 5,6-dihydropyrimidine amidohydrolase, or DHP, is the second enzyme in uracil and thymine catabolism. However, in normal human extrahepatic tissues, DPYS, rather than dihydrouracil dehydrogenase, is the rate-limiting enzyme in the pyrimidine base catabolic pathway. DHPase in solid tumors is increased when compared with normal tissues(PMID: 8307005).Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"