DOK4 antibody

Cat.#: 110052

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Product Information

  • Product Name
    DOK4 antibody
  • Documents
  • Description
    DOK4 Rabbit Polyclonal antibody. Positive IHC detected in human prostate cancer tissue. Positive WB detected in Transfected HEK-293 cells.
  • Tested applications
    ELISA, IHC, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    dOCking protein 4 antibody; DOK4 antibody; FLJ10488 antibody; Insulin receptor substrate 5 antibody; IRS 5 antibody; IRS5 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of DOK4 recombinant protein (Accession Number: XM_047434361). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:1000-1:10000

    IHC: 1:20-1:200

  • Validations

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:110052(DOK4 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:110052(DOK4 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:110052(DOK4 antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:110052(DOK4 antibody) at dilution of 1:50 (under 40x lens)

    Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:110052(DOK4 Antibody) at dilution of 1:2000

    Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:110052(DOK4 Antibody) at dilution of 1:2000

  • Background
    The insulin-receptor substrate family plays important roles in cellular growth, signaling and survival. IRS5/DOK4 is a new member of this family identified, which is known as docking protein 4, or downstream of tyrosine kinase-4. DOK4 might have roles in insulin and IGF-1 signaling as well. Expression of IRS5/DOK4 is regulated epigenetically via histone acetylating at its promoter. DOK4 is required at early stages in the myelination process, including the initial interaction with the axon, and is also involved in Schwann cell migration and proliferation, it also regulates GDNF-mediated neurite outgrowth during neuronal development through activation of the Rap1-ERK1/2 pathway. DOK4 may represent a novel negative regulator of T cells as other DOK family members like DOK1 and DOK2.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"