DOK3 antibody

DOK3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

DOK3 Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma tissue. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 53kd

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

dOCking protein 3 antibody; DOK3 antibody; DOKL antibody; FLJ22570 antibody; FLJ39939 antibody

Rabbit IgG

This antibody was obtained by immunization of DOK3 recombinant protein (Accession Number: NM_001375799). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The adaptor proteins downstream of kinase 1 (DOK1) to DOK3 are mainly found in immune cells, and they are closely related, with some functional redundancy, although each DOK protein has distinct properties and functions. DOK1 to DOK3 inhibit LPS responses. DOK proteins have an N-terminal pleckstrin homology (PH) domain, a phosphotyrosine-binding (PTB) domain, and four tyrosine-containing motifs that can bind to Src homology 2 (SH2) domains when phosphorylated. DOK3 was also shown to have an inhibitory role as it restricts Ca2+ and JNK activation in B cell receptor signaling. The MW of this protein is 53 kDa, and this antibody specially recognises the 53 kDa protein.