DICER1 antibody

DICER1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

DICER1 Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue, human lung cancer tissue. Positive IF detected in HepG2 cells. Positive IP detected in Jurkat cells. Positive WB detected in K-562 cells, Jurkat cells. Observed molecular weight by Western-blot: 220-250kd,90kd

ELISA, WB, IHC, IF, IP

Human,Mouse,Rat; other species not tested.

DCR1 antibody; Dicer antibody; dicer 1 antibody; ribonuclease type III antibody; DICER1 antibody; Endoribonuclease Dicer antibody; Helicase MOI antibody; Helicase with RNase motif antibody; HERNA antibody; KIAA0928 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_030621). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

DICER1, also named as DICER, HERNA and KIAA0928, belongs to the helicase family and Dicer subfamily. It is required for formation of the RNA induced silencing complex (RISC). DICER1 is a component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. DICER1 cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs. The antibody is specific to DICER1.

• Anglesio MS, Wang Y, Yang W. Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage. The Journal of pathology. 229(3):400-9. 2013.