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DAPP1 antibody

Cat.#: 109864

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Product Information

  • Product Name
    DAPP1 antibody
  • Documents
  • Description
    DAPP1 Rabbit Polyclonal antibody. Positive IF detected in Hela. Positive IHC detected in human liver cancer.
  • Tested applications
    ELISA, IHC, IF
  • Species reactivity
    human, mouse, rat; other species not tested.
  • Alternative names
    DAPP1 antibody; BAM32 antibody; DKFZp667E0716 antibody; hDAPP1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of DAPP1 recombinant protein (Accession Number: NM_014395). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    IHC: 1:20-1:200

    IF: 1:20-1:200

  • Validations

    Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:109864(DAPP1 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:109864(DAPP1 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:109864(DAPP1 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:109864(DAPP1 antibody) at dilution of 1:100 (under 10x lens)

    Immunofluorescent analysis of Hela cells, using DAPP1 antibody Catalog No:109864 at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

    Immunofluorescent analysis of Hela cells, using DAPP1 antibody Catalog No:109864 at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

  • Background
    DAPP1 was identified as dual adaptor for phosphotyrosine and 3-phosphoinositides, a novel 280 amino acid protein which contains a putative myristoylation site at its N-terminus followed by a SH2 and a PH domain at its C-terminus (PMID: 10432293). DAPP1 is also referred to B cell adaptor molecule of 32 kDa (Bam32), and is expressed by B lymphocytes, but not T lymphocytes or nonhematopoietic cells. DAPP1/Bam32 was shown to regulate BCR signaling downstream of phosphatidylinositol 3-kinase (PI3K) (PMID: 10770799). Furthermore, DAPP1/Bam32 may server to integrate PI3K and Src kinase signaling to promote Rac-dependent B cell adhesive interactions important for antigen presentation function (PMID: 20495066).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"