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Product Name
CYP4F8 antibody
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Description
CYP4F8 Rabbit Polyclonal antibody. Positive IHC detected in human skin tissue, human kidney tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
CPF8 antibody; CYP4F8 antibody; CYPIVF8 antibody; CytOChrome P450 4F8 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_007253). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemistry of paraffin-embedded human skin tissue slide using Catalog No:109709(CYP4F8 Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human skin tissue slide using Catalog No:109709(CYP4F8 Antibody) at dilution of 1:50 (under 40x lens)
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Background
CYP4F8, also named as CPF8, belongs to the cytochrome P450 family. Cytochromes P450 are a group of heme-thiolate monooxygenases. CYP4F8 hydroxylates arachidonic acid (20:4n-6) to (18R)-hydroxyarachidonate. CYP4F8 shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. CYP4F8 catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3-hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). It catalyzes hydrxylation of PGI2 and carbaprostacyclin. The antibody has no cross reaction to other CYP4F member
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